НИЦЭБ РАН

Основные направления исследований:

1.    Проблема новых («появляющихся») загрязнителей окружающей среды. Нецелевой («проба неизвестного состава») и целевой анализ новых и малоизученных загрязнителей окружающей среды в водных объектах Северо-Западного региона.
2.     Проблема вредоносных «цветений» водоемов: исследование структуры фитопланктонных сообществ и их токсичных метаболитов.
3.    Разработка аналитических процедур для определения следовых количеств антропогенных и природных экотоксикантов в объектах окружающей среды.
4.      Инструментальные физико-химические методы аналитической химии (методы хромато-масс-спектрометрии, гигантского комбинационного рассеяния (ГКР), биосенсорные системы).
5.    Изучение процессов трансформации различных групп антропогенных экотоксикантов.
6.    Прогноз и изучение биологически-активных свойств вновь синтезированных элементорганических соединений.

Темы в плане НИР на 2022-2024 гг.
ИДЕНТИФИКАЦИЯ НОВЫХ И МАЛОИЗУЧЕННЫХ ПРИРОДНЫХ И АНТРОПОГЕННЫХ ЭКОТОКСИКАНТОВ В ОБЪЕКТАХ ОКРУЖАЮЩЕЙ СРЕДЫ, ИССЛЕДОВАНИЕ МЕХАНИЗМОВ ИХ ТРАНСФОРМАЦИИ И ВОЗДЕЙСТВИЯ НА БИОТУ 
Рег. № НИОКТР 122041100086-5

Основные публикации (Sсopus, WEB of Science за 2020-2024 гг.)

1. Berezina, N.A., Sukhikh, N.M., Egorova, A.V. Zhakovskaya, Z.A.   Physiological and Reproductive Disorders of Baltic Amphipods Gmelinoides fasciatus Exposed to 4-tert-Octylphenol. Contemp. Probl. Ecol. 17, 192–200 (2024). https://doi.org/10.1134/S199542552402001X
2. Gabyshev V.A., Sidelev S.I., Chernova E.N., Vilnet A.A., Davydov D.A., Barinova S., Gabysheva O.I., Zhakovskaya, Z.A., Voronov I.V. Year-Round Presence of Microcystins and Toxin-Producing Microcystis in the Water Column and Ice Cover of a Eutrophic Lake Located in the Continuous Permafrost Zone (Yakutia, Russia) // Toxins. – 2023. – Vol. 15. – Iss. 7. https//doi.org/10.3390/toxins15070467
3. Gabyshev V., Davydov D., Vilnet A., Sidelev S., Chernova E., Barinova S., Gabysheva O., Zhakovskaya Z. Gloeotrichia cf. natans (Cyanobacteria) in the Continuous Permafrost Zone of Buotama River, Lena Pillars Nature Park, in Yakutia (Russia) // Water. – 2023. – Vol. 15. – Iss. 13. https//doi.org/10.3390/w15132370
4. Kurbatova S., Berezina N., Sharov A., Chernova E., Kurashov E., Krylova Y., Yershov  I., Mavrin  A., Otyukova N., Borisovskaya E., Fedorov R. Effects of Algicidal Macrophyte Metabolites on Cyanobacteria, Microcystins, Other Plankton, and Fish in Microcosms // Toxins. – 2023. – Vol. 15. – Iss. 9. https//doi.org/10.3390/toxins15090529  
5. Gabyshev V.A., Sidelev S.I., Chernova E.N., Gabysheva O.I., Voronov I.V., Zhakovskaya Z.A. Limnological Characterization and First  Data on the Occurrence of Toxigenic Cyanobacteria and Cyanotoxins in the Plankton of Some Lakes in the Permafrost Zone (Yakutia, Russia) // Contemporary Problems of Ecology. – 2023. – Vol. 16. – No. 2. – Pp. 89-102. https//doi.org/10.1134/S1995425523020087
6. Медведева Н.Г., Зайцева Т.Б., Кузикова И.Л, Чернова Е.Н. Биодеструкция микроцистина-LR автохтонной микробиотой разнотипных водных объектов Северо-Запада России // Известия РАН. Серия Биологическая. – 2023. – № 6. – С. 687-699. https//doi.org/10.31857/S1026347022600820
7. Larisa F. Litvinchuk, Andrey N. Sharov, Ekaterina N. Chernova, Vyacheslav V. Smirnov,  Nadezhda A. Berezina Mutual links between microcystins-producing cyanobacteria and plankton community in clear and brown northern lakes. / Food Webs 35 (2023) e00279 https://doi.org/10.1016/j.fooweb.2023.e00279
8. Bikbaeva Gulia, Pilip Anna, Egorova Anastasia, Kolesnikov Ilya, Pankin Dmitrii, Laptinskiy Kirill, Vervald Alexey, Dolenko Tatiana, Leuchs Gerd, Manshina Alina All-in-One Photoactivated Inhibition of Butyrylcholinesterase Combined with Luminescence as an Activation and Localization Indicator: Carbon Quantum Dots@Phosphonate Hybrids. Nanomaterials 2023, 13(17), 2409 DOI: 10.3390/nano13172409  
9. Bikbaeva Gulia, Egorova Anastasia, Sonin Nikolai, Pilip Anna, Kolesnikov Ilya, Pankin Dmitrii, Boroznjak Roman, Manshina Alina Vinyl phosphonates as photopharmacological agents – laser induced cis‐trans isomerization and butyrylcholinesterase activity. ChemPhotoChem 2023 DOI: 10.1002/cptc.202300  
10. Daria M. Krygina, Eugene V. Sivtsov, Yuliya N. Pavlyukova, Ekaterina N. Chernova, Mariya A. Skryl’nikova, Vadim A. Baigildin, Aleksandra M. Puzyk , Alexander A. Oskorbyn, Rostislav E. Trifonov, Pavel A. Aleshunin, Vladimir A. Ostrovskii 5-Vinyl-1H-Tetrazole. // Molbank 2023, v.2023(1), M1565; https://doi.org/10.3390/M1565  
11.    Ershov I.S., Esikov K.A., Nesterova O.M., Skryl’nikova M.A., Khramchikhin A.V., Shmaneva N.T., Chernov I.S., Chernova E.N., Puzyk A.M.; Sivtsov E.V. et al. 3-(5-Phenyl-2H-tetrazol-2-yl)pyridine. // Molbank 2023,v. 2023, M1598. https://doi.org/10.3390/M1598
12. Metelkova L.,  Zhakovskaya Z., Kukhareva G.., Voskoboinikov G.., Zimina O. Organotin compounds (OTs) in surface sediments, bivalves and algae from the Russian coast of the Barents Sea (Kola Peninsula) and the Fram Strait (Svalbard Archipelago) // Environmental Science and Pollution Research. – 2022. – V.29 – P. 34659–34669. https://doi.org/10.1007/s11356-021-18091-0.
13. Pesnya D.S., Kurbatova S.A., Sharov A.N., Chernova E.N., Yershov I.Y., Shurganova G. V., Vodeneeva E. L. Genotoxicity of Natural Water during the Mass Development of Cyanobacteria Evaluated by the Allium Test Method: A Model Experiment with Microcosms // Toxins. – 2022. – V.14. – P. 359. http://dx.doi.org/10.3390/toxins14050359
14. Ivanova K.A., Chernova E.N., Kulaeva O.A., Tsyganova A.V., Kusakin P. G.., Russkikh I.V., Tikhonovich I.A., Tsyganov V.E. The Regulation of Pea (Pisum sativum L.) Symbiotic Nodule Infection and Defense Responses by Glutathione, Homoglutathione, and Their Ratio // Frontiers in Plant Science. – 2022. – V. 13. – P.843565. http://dx.doi.org/10.3389/fpls.2022.843565
15.    Morozov A. A., Yurchenko V. V., Berezina N. A., Sladkova S. V., Chernova E. N. Biochemical and respiratory parameters in a gastropod Radix balthica exposed to diclofenac // Comparative Biochemistry and Physiology. Part C: Toxicology & Pharmacology. – 2022. – V. 252. – P. 109240. https://doi.org/10.1016/j.cbpc.2021.109240.
16.    Khramchikhin A. V., Skryl'nikova M. A., Esaulkova I. L., Sinegubova E. O., Zarubaev V. V., Gureev M. A., Puzyk A. M., Ostrovskii V. A. Novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4 b][1,3,4]thiadiazepine derivatives: synthesis, anti-viral in vitro study and target validation activity // Molecules. – 2022. – V.27(22). – P.7940. https://doi.org/10.3390/molecules2722794
17.    Berezina N. A., Sharov A. N., Chernova E. N., Malysheva O. A. Effects of Diclofenac on the Reproductive Health, Respiratory Rate, Cardiac Activity, and Heat Tolerance of Aquatic Animals // Environmental Toxicology and Chemistry. – 2022. – Vol. 41, No. 3. – P. 677–686. https://doi.org/10.1002/etc.5278
18.    Kurbatova S. A., Berezina N. A., Sharov A. N., Ershov I. Yu, Otyukova N. G., Chernova E. N., Borisovskaya E. V. Interactions of Cyanobacteria and Aquatic Organisms: Can Crustaceans Facilitate Cyanobacteria Bloom? // Russian Journal of Ecology. – 2022. – Vol. 53, No. 6. – Р. 565–572. http://dx.doi.org/10.1134/S1067413622060078
19. Kolesnikov I., Mamonova D., Pankin D., Bikbaeva G., Khokhlova A., Pilip A., Egorova A., Zigel V., Manshina A. Photoswitchable Phosphonate‐fullerene Hybrids with Cholinesterase Activity // Photochemistry and Photobiology. – 2022. – https://doi.org/10.1111/php.13720  
20. Zhakovskaya Z., Metelkova L., Kukhareva G., Egorova A., Prishchepenko D.V., Neevin I.A., Ryabchuk D.V., Grigoriev A.G., Krek A.V. Mobility of metal-organic pollutants in the emerging coastal-marine sediment of the Baltic Sea: the case-example of organotin compounds in sediments of the Gulf of Finland 2022 // Journal of Sea Research. – 2022. –102307. https://doi.org/10.1016/j.seares.2022.102307
21. Kuzikova I., Andronov E., Zaytseva T., Metelkova L., Zhakovskaya Z., Medvedeva N. A microcosm approach for evaluating the microbial nonylphenol and butyltin biodegradation and bacterial community shifts in co‑contaminated bottom sediments from the Gulf of Finland, the Baltic Sea // Environmental Science and Pollution Research. – 2022. – V. 29. – P. 69849–69860. https://doi.org/10.1007/s11356-022-20751-8  
22. Keliri E., Paraskeva C., Sofokleous A., Chernova E., et al. Occurrence of a single-species cyanobacterial bloom in a lake in Cyprus: monitoring and treatment with hydrogen peroxide-releasing granules // Environmental Sciences Europe. – 2021. – Vol, 33, No 1. – P.31. DOI:10.1186/s12302-021-00471-5
23. Denisov D.B., Chernova E.N., Russkikh I.V. Toxic Cyanobacteria in the Arctic Lakes: New Environmental Challenges. A Case Study // Springer Geography. – 2021. – P. 161–170. DOI:10.1007/978-3-030-75285-9_15
24. Chernova E., Zhakovskaya Z., Berezina N. Occurrence of pharmaceuticals in the Eastern Gulf of Finland (Russia) // Environmental Science and Pollution Research. – 2021. – DOI:10.1007/s11356-021-15250-1
25. Pankin D., Khokhlova A., Kolesnikov I., Vasileva A., Pilip A., Egorova A., Erkhitueva E., Zigel V., Gureev M., Manshina A. Laser-induced twisting of phosphorus functionalized thiazolotriazole as a way of cholinesterase activity change // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. – 2021. – 246. DOI: 10.1016/j.saa.2020.118979
26. Kolesnikov I., Pankin D., Khokhlov A., Pilip A., Egorova A., Zigel V., Gureev M., Manshina A., Leuchsef G. / Laser-induced switching of the biological activity of phosphonate molecules // New J. Chem. – 2021. – Vol. 45. – P. 15195-15199. DOI: 10.1039/D1NJ02487F
27. Metelkova L.O., Zhakovskaya Z.A., Kukhareva G.I., Voskoboinikov G.M., Matishov G.G. Organotin Compounds (OTCs) in Saccharina latissima (Phaeophyceae) from the Barents Sea // Doklady Biological Sciences. – 2021. – Vol. 497. – P. 56–58 DOI: 10.1134/S0012496621020083
28. Воскобойников Г.М., Малавенда С.В., Метелькова Л.О. Роль водорослей-макрофитов в биоремедиации от нефтепродуктов // Морской биологический журнал. – Т.6. №3. – С. 35-43, (2021), DOI: 10.21072/mbj.2021.06.3.04
29. Chernova E., Sidelev S., Russkikh I., Korneva L., Solovyova V., Mineeva N., Stepanova I., Zhakovskaya Z. Spatial distribution of cyanotoxins and ratios of microcystin to biomass indicators in the reservoirs of the Volga, Kama and Don Rivers, the European part of Russia // Limnologica. – 2020. – 84. – P. 125819. DOI: 10.1016/j.limno.2020.125819  
30. Sidelev S., Zubishina A., Chernova E.. Distribution of microcystin-producing genes in Microcystis colonies from some Russian freshwaters: Is there any correlation with morphospecies and colony size? // Toxicon. – 2020. – Vol. 184. – P. 136-142. DOI: 10.1016/j.toxicon.2020.06.005
31. Voskoboinikov G. M., Ryzhik I. V., Salakhov D. O., Metelkova L. O., Zhakovskaya Z. A., Lopushanskaya E. M.. Absorption and Conversion of Diesel Fuel by the Red Alga Palmaria palmata (Linnaeus) F. Weber et D. Mohr, 1805 (Rhodophyta): The Potential Role of Alga in Bioremediation of Sea Water // Russian Journal of Marine Biology. – 2020. Vol. 46. – P. 113-118. DOI: 10.1134/S1063074020020108
32. Sidelev S., Koksharova O., Babanazarova O., Fastner J., Chernova E., Gusev E. Phylogeographic, toxicological and ecological evidence for the global distribution of Raphidiopsis raciborskii and its northernmost presence in Lake Nero, Central Western Russia // Harmful Algae. 2020.– Vol. 98. – P. 101889. DOI: 10.1016/j.hal.2020.101889
33. Воякина Е.Ю., Русских Я.В., Чернова Е.Н., Жаковская З.А. Токсичные цианобактерии и их метаболиты в водоёмах Северо-Запада России // Теорeтическая и прикладная экология. – 2020. –T. 1. – С. 124-129. DOI: 10.25750/1995-4301-2020-1-124-129
34. Voskoboinikov G, Malavenda S, Metelkova L. The role of fucus algae in bioremediation of coastal waters of the Barents Sea from oil products // IOP Conference Series: Earth and Environmental Science. – 2020. – 539. – P. 012035. DOI: 10.1088/1755-1315/539/1/012035

Гранты:
Грант РНФ № 23-13-00224 «Разработка новых биологически активных азот-, серу- и кислородсодержащих гетероциклических соединений мультитаргетного действия».